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The place is the lab?
reNEW, College of Copenhagen, Denmark
Lab web site: https://renew.ku.dk/analysis/reseach-groups/zylicz-group/
Analysis abstract
Jan Żylicz: Our major focus is on unravelling the intricate molecular mechanisms via which chromatin and metabolism regulate early mammalian improvement. The staff explores basic questions reminiscent of how world modifications in metabolism result in particular outcomes, the causal relationship between chromatin and gene expression alterations throughout lineage specification, and the organic significance of the coupling between metabolism and epigenetics.
Lab roll name
Sandra Bages Arnal: Lab Supervisor – I maintain the final issues within the lab, like ordering, group, mice colony administration, and so forth. And I assist folks with their initiatives when wanted.
Arnau Casoliba Melich: PhD pupil – I research the position of metabolism in selling and sustaining the trophoblast lineage in mouse fashions utilizing degron techniques and CRISPR interference.
Antar Drews: PhD pupil – My curiosity lies in uncovering novel epigenetic regulators of lineage destiny within the early human embryo, with a selected concentrate on the trophectoderm.
Eleni Kafkia: PostDoc – My scientific pursuits lie in understanding the metabolic structure routings throughout pluripotent state transitions and the way these are particularly intertwined with chromatin alterations. To elucidate this, I’m using a mix of 13C-isotope metabolic flux analyses, chemoproteomic profiling and CRISPRi/a applied sciences.
Viktoria Lavro: PhD pupil – I’m utilizing single-cell sequencing methods to analyze the causes behind embryo failure and the constancy of in vitro fashions in recapitulating key options of improvement.
David Pladevall Morera: PostDoc – I take advantage of CRISPR interference and high-throughput microscopy to decipher the position of metabolic enzymes in regulating chromatin and cell states throughout early embryonic improvement, particularly on the stage of embryo implantation.
Nikolaos Stamidis: PhD pupil – I’m utilizing in vivo and in vitro approaches to grasp the position of histone acetylation in early mouse improvement, particularly on the subject of regulation of chromatin and gene expression.
Karlien van Nerum: PhD pupil – I’m attempting to grasp the affect of the interplay between metabolism and epigenetics throughout trophectoderm specification and differentiation, however largely I identical to to tradition cells.
Anne Wenzel: Bioinformatician – Steering clear from the moist lab always, I attempt to make sense of the info that will get generated by my teammates. I combine varied omics knowledge or helping my lab mates of their knowledge analyses.
Jan Żylicz: PI – I maintain folks, grants, ethics and papers; additionally, I are inclined to occupy folks’s benches after I need to present that he can nonetheless do experiments.
Favorite approach, and why?
Jan Żylicz: Positively ChIP-seq, stunning peaks give me nice satisfaction and I can discover them for days. This course of sometimes serves because the preliminary step in formulating an in depth speculation, which may later be examined functionally.
Other than your personal analysis, what are you most enthusiastic about in developmental and stem cell biology?
Jan Żylicz: The position of mechanics in each side of a cell’s functioning by no means ceases to amaze me! I’m excited when beforehand unanticipated views of developmental biology emerge. Our discipline is quickly progressing on this course. Certainly, final years have demonstrated clear couplings between cell and tissue mechanics with transcription, chromatin, and even metabolism. Regardless of these thrilling discoveries, the molecular understanding of those inter-modal couplings stays poorly understood and lacks integration into in silico modeling. I can’t watch for this to really occur!
How do you method managing your group and all of the completely different duties required in your job?
Jan Żylicz: I take into account my major duty to be caring for your entire staff. I present assist in varied points, reminiscent of encouraging them to generate concepts, helping in troubleshooting, aiding with writing duties, and serving to them plan for his or her future steps. Nonetheless, in observe, it could possibly develop into difficult to handle a number of duties concurrently. Given my inherent disorganization, I depend on many instruments to maintain issues organized and on observe.
What’s the neatest thing about the place you’re employed?
Arnau Casoliba Melich: The folks and specifically labmates are very supportive. All of us undergo comparable experiences and understanding individuals are there for you may be very reassuring.
Antar Drews: Having labmates that assist me with (and typically stop me from) consuming regarding quantities of gummy bears within the workplace.
Eleni Kafkia: I actually recognize the supportive and collaborative ambiance inside and throughout the labs on the institute.
Viktoria Lavro: The atmosphere may be very supportive, not simply inside my group, but additionally throughout different analysis labs. On prime of that, I actually recognize our central location within the metropolis, in a energetic space of lovely Copenhagen.
David Pladevall Morera: The collaborative atmosphere throughout labs in our institute and the at all times supportive colleagues.
Nikolaos Stamidis: The people from the institute are those who create an atmosphere that you simply actually need to work in. Moreover, I want to spotlight the institute’s unbelievable services and its central location within the coronary heart of Copenhagen, which locations it on the heart of Denmark’s scientific group.
Karlien van Nerum: The worldwide treats when our colleagues return from holidays.
Anne Wenzel: We have now a extremely interdisciplinary and worldwide atmosphere with ample alternatives for change in scientific and social settings, such because the ChatBPC (BioinformaticsPeerCommunity) conferences and “Friday Hygge”.
Jan Żylicz: Our institute has a close-knit ambiance, the place you get to know everybody personally. Moreover, attributable to our shared use of comparable instruments and approaches, we incessantly collaborate with labs positioned proper subsequent door.
What’s there to do outdoors of the lab?
Sandra Bages Arnal: Throughout summer time there may be loads of stay music across the metropolis, some free of charge, and on the whole there’s a very good ambiance all over the place.
Arnau Casoliba Melich: You’ve gotten a lot to do in Copenhagen, from cute cafés to nice parks, there may be at all times a brand new factor to do. I specifically just like the climbing gyms across the metropolis.
Antar Drews: Though Copenhagen is just not well-known for having nice climate, there are many cozy cafés and bars to cover from the rain! Additionally, individuals are very sporty and there’s a massive working group right here, which I personally discover very motivating.
Eleni Kafkia: The focus and variety of museums, galleries, occasions, and actions make Copenhagen a metropolis with extremely wealthy cultural choices. This, together with Copenhagen’s worldwide ambiance that melds native traditions with international influences, contributes to its distinct cultural uniqueness.
Viktoria Lavro: When the climate is nice, the town actually comes alive as everybody takes the chance to take pleasure in being open air and there are limitless occasions to take a look at. However it’s also possible to at all times discover one thing enjoyable to do on wet days, I significantly take pleasure in attending live shows and enjoying board video games in cafés.
David Pladevall Morera: I like Copenhagen on the whole and the way worldwide the town is. Notably, I take pleasure in attempting the various completely different eating places that the town presents. Though it’s a small metropolis, as a capital, yow will discover nice cultural and sport occasions all 12 months round.
Nikolaos Stamidis: I actually consider that Copenhagen is without doubt one of the finest cities to stay in. The standard of life may be very excessive. Regardless of the Scandinavian climate, there are a lot of parks across the metropolis the place folks may be seen exercising all through your entire 12 months. On prime of that, there are at all times occasions to attend, and individuals are at all times up for going out for a beer.
Karlien van Nerum: As a capital metropolis, Copenhagen may be very vibrant and worldwide. You’ll be able to at all times discover one thing distinctive to do and go on little adventures.
Anne Wenzel: Copenhagen is a really livable metropolis. Regardless of its small dimension, which implies that one can simply get all over the place by bike, it’s nonetheless the capital and presents all types of leisure, a lot of live shows and so forth.
Jan Żylicz: The meals scene in Copenhagen is really phenomenal! From avenue and luxury meals to extravagant new Scandinavian delicacies we’re spoiled for selection.
(No Rankings But)
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