World AIDS Day, noticed yearly on December 1st, is as a world initiative devoted to elevating consciousness about HIV/AIDS. Since its institution in 1988, this occasion has turn out to be one of the vital important well being consciousness campaigns worldwide; uniting communities, organizations, and people within the collective effort in opposition to HIV/AIDS. On this weblog, we acknowledge the progress made within the battle in opposition to HIV/AIDS by highlighting the impactful analysis contributions throughout the BMC Collection.

Natasha Hirst 1 Dec 2023

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BMC Public Well being – Feasibility and acceptability of peer-delivered HIV self-testing and PrEP for younger girls in Kampala, Uganda

This pilot examine in Uganda aimed to evaluate the feasibility and acceptability of peer-delivered HIV self-tests (HIVST) and oral pre-exposure prophylaxis (PrEP) to younger girls with suboptimal PrEP adherence. Regardless of adolescent ladies and younger girls (AGYW) accounting for a disproportionate 29% of recent HIV infections in Uganda, this group stays underrepresented within the inhabitants. The examine concerned 30 younger girls aged 18–24 with suboptimal PrEP adherence. Peer-delivered interventions have been well-received, with excessive completion charges at three and 6 months. Moreover, qualitative evaluation revealed constructive experiences and motivation by way of peer help, emphasizing the significance of peer help in adherence to PrEP. The examine concludes that peer supply of those interventions is each possible and acceptable, suggesting potential effectiveness in addressing HIV prevention challenges amongst African AGYW. Future managed research are beneficial to additional consider effectiveness on a wider scale.

BMC Infectious Illnesses – Complete data about HIV/AIDS and related elements amongst adolescent ladies in Rwanda: a nationwide cross-sectional examine

On this examine researchers investigated the elements influencing complete data of HIV/AIDS amongst adolescent ladies in Rwanda utilizing knowledge from the 2020 Rwanda Demographic and Well being Survey. They discovered that of the 3258 contributors, 53.6% demonstrated complete HIV data. These with secondary training, medical health insurance, a cell phone, publicity to tv, and a historical past of HIV testing had the place extra prone to have a complete data of HIV/AIDS. Conversely, ladies in Kigali and Northern areas, in addition to these practising the Anglican faith, had decrease odds. The findings of this examine spotlight the significance of increasing HIV preventive training by way of training and social media. Continued involvement of decision-makers and neighborhood actors, significantly spiritual leaders, is essential for enhancing complete understanding of HIV/AIDS amongst adolescent ladies.

BMC Major Care – Determinants of entry to normal follow in a shared care mannequin for folks residing with HIV: a qualitive examine of sufferers’ views in an Australian rural neighborhood

This examine investigates the challenges and facilitators of implementing shared care fashions for folks residing with HIV in rural Australia. With improved HIV administration, the getting old HIV inhabitants faces comorbidities, necessitating coordinated care between normal practitioners and specialists. Nonetheless, these in rural areas expertise limitations to accessing shared care. 13 qualitative interviews revealed that accessibility to normal follow considerably influenced shared care engagement, furthermore, contributors doubted the additive worth of normal practitioners. Healthcare beliefs, stigma, and preferences for specialist care additional impacted the usage of shared care. The authors of the examine discovered continuity of care on the whole follow helped facilitated shared care, nevertheless, logistical points equivalent to affordability and transport posed challenges. They concluded that overcoming affected person priorities, anticipated stigma, and useful resource limitations in rural healthcare is essential for efficient shared care. Constructing rapport with normal practitioners and guaranteeing continuity of care are important methods for high quality main care in shared fashions, supported by specialist physicians.

BMC Immunology – HIV particular Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection

In fishing communities close to Lake Victoria in Uganda, the place HIV prevalence is excessive, Schistosoma mansoni (S. mansoni) an infection charges are additionally important. Greater than 50% of native fishermen are contaminated with S. mansoni. The authors of this examine investigated how S. mansoni coinfection would possibly modify immune responses in opposition to HIV. Utilizing polychromatic move cytometry and Gran-ToxiLux assays, the examine in contrast HIV-specific responses, T cell phenotypes, and antibody-dependent cell-mediated cytotoxic (ADCC) efficiency and titres between people with HIV-S. mansoni coinfection and people with HIV alone. Apparently, the findings revealed that S. mansoni coinfection was related to modified anti-HIV responses, together with a decrease frequency of bifunctional CD4 T cells, greater total CD4 T cell activation, and decrease HIV ADCC antibody titres in comparison with people with HIV alone. The outcomes counsel that S. mansoni an infection impacts T cell and antibody responses to HIV in coinfected people, highlighting the significance of understanding the impression of S. mansoni remedy upon HIV-specific immune responses and illness development.

BMC Well being Providers Analysis – Complete data about HIV/AIDS and related elements amongst adolescent ladies in Rwanda: a nationwide cross-sectional examine

The authors of this mixed-methods examine investigated the attitudes, facilitators, and limitations to HIV drug resistance mutations (DRM) testing amongst pregnant girls and kids on antiretroviral remedy (ART) in Kenya. Regardless of decrease charges of viral suppression on this inhabitants, the importance of DRM in remedy selections is acknowledged, resulting in the scaling up of nationwide DRM testing packages in resource-limited settings. They performed interviews with adolescents, caregivers, pregnant girls, suppliers, and policymakers in 5 HIV remedy amenities. Outcomes from the interviews highlighted the worth of DRM testing in scientific decision-making and affected person reassurance, with a need amongst suppliers and policymakers for a streamlined, doubtlessly decentralized testing course of with larger affected person and supplier “empowerment” to extend consolation with testing protocols. The examine highlights the potential of DRM testing to enhance affected person well being outcomes and emphasizes the necessity for simplified and environment friendly implementation methods.

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The BMC Collection is keen about furthering analysis in HIV/AIDS and has a number of Collections open which researchers could also be fascinated with submitting their invaluable HIV/AIDS analysis too: