The manufacturing of superior biofuels represents a near-term alternative to decarbonize the heavy car transportation sector. Nonetheless, vital boundaries should be overcome and profitable deployment of those applied sciences would require (i) catalyst and course of growth to scale back value and enhance carbon utilization and (ii) industry-relevant validation of operability to de-risk scale-up. Herein, we search to handle these challenges for an built-in two-step course of involving catalytic quick pyrolysis (CFP) adopted by co-hydrotreating of bio-oil with refinery streams. Technoeconomic and lifecycle evaluation based mostly on the info introduced herein reveal the potential to generate low-carbon transportation fuels and chemical co-products with a modelled promoting worth of $2.83 gasoline gallon equal (2016$) and a 78% discount in greenhouse fuel emissions in comparison with fossil-based pathways. The feedstock for this analysis was a mix of fifty wt% loblolly pine and 50 wt% waste forest residues, and the CFP step was carried out utilizing an ex situ mounted mattress of Pt/TiO₂ with co-fed H₂ at atmospheric strain. In comparison with earlier state-of-technology benchmarks, developments in catalyst design and synthesis methodology enabled a four-fold discount in Pt loading and a 400% improve in time on stream with out negatively impacting upgrading efficiency. Moreover, a first-of-its-kind built-in evaluation of waste fuel adsorption confirmed close to quantitative restoration of acetone and 2-butanone, which collectively signify roughly 5% of the biomass carbon. The valorization of those co-products opens alternatives to help decarbonization of the chemical sector whereas concurrently bettering the general course of carbon effectivity to >40%. After condensation, the CFP-oil was co-hydrotreated with straight run diesel (10 : 90 vol%) to attain 95% biogenic carbon incorporation. The oxygen content material of the hydrotreated oil was under detection limits, and the diesel fraction exhibited a cetane quantity and cloud level appropriate for a completed gas. This manuscript concludes by highlighting remaining analysis wants related to bettering thermal administration throughout catalyst regeneration, mitigating catalyst deactivation attributable to inorganic deposition, and demonstrating the sturdiness of biomass feeding techniques when operated in hydrogen-rich environments.