The usefulness of ketonization reactions for the valorization a large plethora of biomass-derived carboxylic acids is widely known; nonetheless, the total potential of this response has but to be suitably developed for the manufacturing of excessive added-value fragrant and/or aliphatic uneven ketones. For that reason, herein we report for the primary time within the literature, the continuous-flow, gas-phase synthesis of 2-acetyl furan (AF) by way of the catalytic cross-ketonization of bio-based 2-methyl furoate (2-MF) and acetic acid (AA) over a easy and low-cost ZrO₂ catalyst. Curiously, AF is taken into account a priceless meals additive and a pharmaceutical intermediate for the synthesis of antibiotics. The optimization of the molar ratio between reactants at 350 °C allowed to attain 87 % selectivity in AF at 90 % 2-MF conversion, with a space-time yield of 0.152 h^-1, a price that’s just like those obtained following conventional Friedel-Crafts acylation and Wacker oxidation routes. However, the E-factor of the herein proposed course of is a number of occasions decrease in comparison with aforementioned conventional routes carried out in liquid section and batch circumstances. Lastly, the flexibility of the cross-ketonisation artificial method was efficiently demonstrated and utilized for the selective synthesis of different priceless acyl furans (i.e., propionyl furan and butyryl furan).