Chemo-biocatalytic synthesis is an efficient strategy to switch biomass into high-value merchandise. Right here, a novel and environment friendly route is proposed in the direction of preparation of furfuryl alcohol from corncob. The novel silica supported SO42–TiO2 catalyst was ready to transform corncob into furfural at 170 °C for 30 min through the use of microwave heating, reaching furfural yield 73.2%. To bio-reduction of furfural to furfuryl alcohol, the novel recombinant E. coli EF22 cells have been efficiently constructed and essentially the most appropriate parameters have been recognized. The immobilization was carried out on E. coli EF22 to enhance their stability and reusability and to find out the optimum parameters of the immobilization course of. Subsequently, chemo-biocatalytic technique of mixing SO42–TiO2/SiO2 chemocatalyst and EF22@SA/Fe3O4 biocatalyst was carried out, reaching furfuryl alcohol productiveness of 0.552 gram FFAC per g xylan. This examine gives a sustainable and environment friendly route for the synthesis of furfural and furfuryl alcohol, but additionally highlights the applicability of chemo-biocatalytic.