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The place is the lab?

In the course of the Aix-Marseille College Campus, on the coronary heart of the Calanques Nationwide Park, on the border of metropolis. Probably the most lovely tutorial spot in France 😉

Lab web site: Neural stem cell plasticity – IBDM | Institut de Biologie du Développement de Marseille (univ-amu.fr)

Analysis abstract

We’re primarily investigating temporal patterning, and the way it hyperlinks growth with regeneration and pediatric cancers. Alongside the years, now we have recognized key components which are sequentially expressed within the embryo and which are vital to make sure that developmental packages unfold with the right timing. Now we have discovered that failure to take action can lock tissues into everlasting growth resulting in aggressive tumors. This mechanism doubtless underlies the emergence of pediatric cancers. We’re subsequently engaged on the assorted mechanisms that regulate temporal transitions throughout growth or that coopt temporal patterning to advertise regeneration or pediatric cancers . Our mannequin organisms are Drosophila and the chick embryo.

Lab roll name

Cédric: As a PI,my on a regular basis work consists in ensuring that everyone is completely happy to return within the lab each morning to make thrilling science.

Dylan: I joined Cedric Maurange’s workforce as postdoc to grasp how miRNAs can regulate the mobile composition, hierarchy, and development of pediatric tumors in an established Drosophila cerebral tumor.

Paul: I’m the workforce bioinformatician, working as a analysis engineer on deciphering how the cell-of-origin impacts the differentiation trajectory of rhabdomyosarcoma.

Lauranne: As a non-permanent engineer, I examine how MYCN or c-Myc overexpression perturbs cell lineage development and cerebellum’s group through the use of chick embryo as examine mannequin.

Shobana: I’m a PhD scholar within the workforce investigating the dynamic function of microRNAs in neuronal maturation in Drosophila

Emma: I’m a PhD scholar engaged on the self-organizing rules governing tumor development and I’m utilizing a mannequin of Drosophila mind tumor in addition to a numerical mannequin of tumor development.

Favorite method, and why?

Cédric: I’m very keen on single-cell methods. It was such an incredible second when my scholar got here with our first single-cell RNA-seq information, again in 2017, which so clearly confirmed the mobile heterogeneity of neuroblast tumors and the way temporal packages are recapitulated in them. It turned clear that this method can be key to unravelling how mobile heterogeneity and hierarchy are regulated in most cancers.

We are actually attempting to make use of single-cell multiomics mixed with computational simulations to decipher how perturbed developmental/temporal trajectories might be corrected in tumors. I’m very grateful to the mathematicians and laptop scientists who allow us to make sense of those complicated datasets.

Other than your individual analysis, what are you most enthusiastic about in developmental and stem cell biology?

Cédric: Normally, the power to measure/visualise a organic course of on the single cell stage, however within the context of a tissue, is absolutely thrilling. In the intervening time, I’m significantly enthusiastic about the potential for exactly measuring the transcriptional exercise of a gene at a given developmental time in a single cell and correlating it with its chromatin setting. Self-organisation in any respect molecular and mobile scales can be fascinating, significantly difficult and enticing as a result of understanding it can require the collaboration of biologists, mathematicians, physicists and laptop scientists.

How do you method managing your group and all of the totally different duties required in your job?

Cédric: Science needs to be about ardour and enjoyable. Individuals within the lab needs to be self-motivated. There are such a lot of mysteries to be solved in biology, it’s straightforward to select up one that you’re significantly keen on and contribute to resolve it. It is rather fascinating additionally to see the place the hunt leads us.

I like to provide time to newcomers within the lab in order that they get aware of the mannequin and take possession of the challenge. Hopefully, after a while they will even include new concepts of the right way to sort out the issue. Now we have weekly lab conferences and my door is all the time open (besides when I’m on Zoom !). I anticipate folks to naturally come to me once they wish to focus on. We ceaselessly do one-to-one conferences to extra exactly assess the present scenario and which factors to focus on. We even have a rising variety of tasks that depends on tight interdisciplinary collaborations. The mixed experience is often a talisman for the sudden.

What’s the neatest thing about the place you’re employed? 

Cédric: The great ambiance, the multi-disciplinarity of the institute and the a number of potentialities of collaborations with the opposite institutes on the campus and all through town – the whole lot in a implausible pure setting and solar all 12 months lengthy.

Dylan: Working within the calanques nationwide park, the Luminy campus web site is phenomenal.

Paul: The great ambiance and the chance to work with scientists with actually numerous analysis fields and pursuits. Furthermore, the lab and the scientific group of Marseille additionally provide many social occasions.

Lauranne: We work in a stunning campus surrounded by nature the place the optimistic ambiance among the many 21 IBDM’s groups not solely throughout work hours but additionally throughout after- work gatherings provides to the general pleasure and satisfaction we discover in our work setting.

Shobana: Along with the institute being multi-disciplinary, the pleasant and interesting ambiance makes it straightforward to method folks for assist or dialogue, additional facilitated by common seminars and after-work classes.

Emma: The IBDM, ideally situated within the calanques nationwide park, advantages from the very good climate of Marseille all 12 months lengthy. Furthermore, the institute gathers many individuals from totally different backgrounds which makes it very interdisciplinary as well as of the great and pleasant ambiance.

What’s there to do outdoors of the lab?

Cédric: Stroll within the Calanques and uncover the assorted panorama of Provence, take pleasure in all of the actions of the colourful metropolis that’s Marseille.

Paul: The lab is ideally positioned within the “Parc Nationwide des Calanques”, a kind of nature spot within the periphery of the massive metropolis of Marseille, providing the chance to do some mountaineering. Within the metropolis heart, there are some museums, malls and so forth. and through winter, an attractive Christmas market on the Vieux-Port.

Shobana: There’s tons to do proper outdoors the lab like mountaineering, climbing or simply strolling. Even looking of the lab window, one can see how lovely and serene it’s being surrounded by the Calanques. A well-equipped sports activities complicated is sort of close by as nicely, providing coaching in several sports activities.

The put up Lab Assembly with the Maurange Lab appeared first on the Node.

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