Porous hole spherical particles profit from particular structural options and engaging physicochemical properties leading to widespread utility. Notably in pharmaceutical engineering, they’ve important benefits for direct compression and drug mixture. Nevertheless, their large-scale utility is severely hindered by the constraints of conventional manufacturing strategies when it comes to the usage of complicated gear, excessive vitality consumption and excessive natural solvent utilization. On this work, now we have developed an oiling-out directional agglomeration technique to supply porous hole indomethacin spherical particles by a easy heating-quenching-drying operation with out the usage of natural solvents and templating brokers. In comparison with industrial flake crystals, the indomethacin spherical merchandise have larger common tensile energy (471% enhance) and better plastic deformability, i.e., higher tabletability and compressibility. Extra importantly, nifedipine is efficiently loaded into porous hole indomethacin spherical particles based mostly on molecular polarity variations. The composite particles with a core-shell construction exhibit glorious powder properties, tableting and anti-degradation efficiency whereas additionally attaining sequential launch of medication. This contribution gives the idea for the event of drug formulation methods and the design of practical crystalline supplies.