Home Chemistry Palladium nanocatalyst assisted in situ regeneration of amino donor in a one-enzyme cascade

Palladium nanocatalyst assisted in situ regeneration of amino donor in a one-enzyme cascade

Palladium nanocatalyst assisted in situ regeneration of amino donor in a one-enzyme cascade

[ad_1]

α-Chiral amines are key intermediates for scalable preparation of bioactive compounds, herein we current a novel palladium-based nanocatalyst able to selectively catalyzing the reductive amination of carbonyl compounds, which permits the in-situ regeneration of amino donors from wasteful co-products in a one-enzyme cascade utilizing ω-transaminase, with out the requirement of the costly coenzyme NAD(P)H. The cascade community combines a ω-transaminase-assisted transamination with a selective reductive amination response facilitated by a heterogeneous palladium-based nanocatalyst. Nitrogen is sourced from hydroxylamine ions to transform generated co-products again into amino donors, yielding chiral amines with distinctive yields of as much as 99% and wonderful enantioselectivity. This chemoenzymatic one-enzyme transamination-reductive amination cascade community is extremely atom-efficient and generates H2O as its sole by-product, demonstrating its potential impression in artificial chemistry and past.

[ad_2]

LEAVE A REPLY

Please enter your comment!
Please enter your name here