Home Chemistry Photoinduced synthesis of C2-linked phosphine oxides by way of radical difunctionalization of acetylene

Photoinduced synthesis of C2-linked phosphine oxides by way of radical difunctionalization of acetylene

Photoinduced synthesis of C2-linked phosphine oxides by way of radical difunctionalization of acetylene

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Herein, we report a photocatalyzed radical difunctionalization of acetylene for the fast synthesis of C2-linked phosphine compounds. The response was initiated by addition of a phosphinoyl radical and follwed by two cascade transformations. One includes a double addition for the formation of DPPE-dioxide analogues and the opposite the place the intermediate vinylphosphine oxide is intercepted by a radical shaped from an oxoheterocycle. This technique options metal-free, delicate situation (rt, 1 atm acetylene), 100% atom economic system and straightforward operation. Moreover, the response will be robustly carried out on decagram scale.

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